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Cholera - Mechanism and Data Handling

Age 16-18 (A-level)

Two powerpoint presentations with accompanying worksheets. The first introduces cholera and explains how it affects the small intestine's transport proteins leading to diarrhoea. The second looks at the December 2008 Cholera outbreak using UN data. The lesson can be introduced with BBC news clips/articles (search for 'Zimbabwe cholera' on the BBC homepage).



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Published 09 Dec 2008

Contributed by Toby Tufton — Experienced contributor

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3 reviews

Anonymous

My class liked this because... It could be improved by...

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Louise Edgeworth - Experienced contributor

Great to have some data handling resources for year 12.

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Abigail Laing - Admin

Great way to pull together the biological mechanism of Cholera with its devastating human impact - best to use this resource while the content is still so topical.

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Extracts from this resource

Cholera - Mechanism (presentation)

1Cholerahttp://en.wikipedia.org/wiki/Image:Vibrio_cholerae.jpgTeachable.net 2008. Some rights reserved.
http://teachable.net/res.asp?r=2057
2http://en.wikipedia.org/wiki/Image:Illu_small_intestine.jpg3LumenEpithelial
cell4Cell membranes have several proteins attached to them5Vibrio cholerae6Secretes a toxin7A which binds to a protein8APart of the toxin enters the cell and binds to a protein9AAn enzyme begins to make a messenger molecule and keeps making it 10AcAMPThis messenger turns on a chloride pump Cl- and keeps it turned on 11AcAMPThis gives the lumen a high chloride concentrationCl-(lowers its water potential)12ACl-Water
Na+ which pulls water in by osmosis which gives you diarrhoea up to a litre per hour until you die13Which is why cholera
wards look like this http://en.wikipedia.org/wiki/Image:Cholera_hospital_in_Dhaka.jpg14A sodium/glucose co-transport molecule which is why ORS (oral rehydration solution) contains glucoseNa+Glucose15http://www.thefirstpost.co.uk/assets/library/081124nipcholera--122753731514380600.jpghttp://en.wikipedia.org/wiki/Image:Cholera_rehydration_nurses.jpgURL of image of Zimbabwean child with with

Cholera - Mechanism and Data Handling (worksheets)

Cholera
Colour and add labels
( Active transport of chloride ions (Cl-)
( Epithelial cell
( Lumen
( Messenger (cAMP)
( Diffusion of sodium ions (Na+)
( Osmosis (diffusion of water)
( Toxin (parts A and B)
( Vibrio cholerae

Add numbers or arrows (or both)
Vibrio cholerae secretes a toxin
Toxin binds to protein
Part A stimulates enzyme to make cAMP
cAMP stimulates chloride pump
Chloride lowers water potential of lumen
Loss of sodium (diffusion) and water (osmosis)
There is another transport protein which involves Na+ and glucose
Draw and label it
This transport is an active / a passive process. It is the basis of ORS which stands for
Zimbabwe Cholera Outbreak Data Handling Worksheet
This graph shows the cumulative number of deaths . Draw a best fit line.
What does cumulative mean?
How many people will have died
by 8th December?
by 20th December?
by Christmas?
Should your line be a straight line or a curve?
Why?

Is it safe to extrapolate beyond the data?
Why / Why not

Which factors affect reliability

Cholera in Zimbabwe (data presentation)

1Cholera in ZimbabweSlides to accompany data-handling worksheet.
The UN Reports button links to a URL. (The daily reports give the appropriate data)
These reports are what the news bulletins were quoting.MapsUN ReportsGraphsTeachable.net 2008. Some rights reserved.
http://teachable.net/res.asp?r=20572UN ReportsGraphshttp://en.wikipedia.org/wiki/Image:LocationZimbabwe.svg3http://ochaonline.un.org/zimbabwe/SituationReports/tabid/3047/language/en-US/Default.aspxZimbabwe Cholera Deaths4http://ochaonline.un.org/zimbabwe/SituationReports/tabid/3047/language/en-US/Default.aspxZimbabwe Cholera Cholera

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